The Mummies’ Medical Secrets? They’re Perfectly Preserved

One of 23 mummies found in a crypt under a church in Vilnius, Lithuania. Credit Kiril Cachovski of the Lithuanian Mummy Project, 2015

Mummified bodies in a crypt in Lithuania are teaching scientists
about health and disease among people who lived long ago.

By NICHOLAS ST. FLEUR/ The New York Times

Hundreds of skeletons have lain scattered around a crypt beneath a church in Vilnius, Lithuania, for centuries. But 23 of these remains are unlike the rest: Flesh wraps their bones, clothes cover their skin, and organs still fill their insides.

They are mummies, and since they were recovered about five years ago, scientists have investigated their secrets, seeking insights into the lives of people in the 17th, 18th and 19th centuries and the diseases they suffered.

“They are so well preserved that they almost look alive,” said Dario Piombino-Mascali, an anthropologist from Italy who has studied the mummies since 2011.

Recently, Dr. Piombino-Mascali and his colleagues have uncovered remnants of the smallpox virus in one of the mummies, gaining new insights into the origins of a deadly scourge that killed an estimated 300 million people in the 20th century alone.

The work follows on their earlier discoveries: signs of rickets, osteoarthritis and intestinal parasites in the mummies. And they are not the only researchers unearthing new findings from the bodies of the long dead but well preserved.

The study of mummified remains in other parts of the world has yielded historical perspective on the spread of deadly diseases and damaging medical conditions, from heart disease in pre-Columbian Americans to various strains of tuberculosis in 19th-century Europeans.

By understanding how long these diseases have been around and mapping them historically, scientists can better tackle them today.

The entrance to the crypt inside the Dominican Church of the Holy Spirit.CreditKiril Cachovski of the Lithuanian Mummy Project, 2015

“Most people don’t realize you can learn about modern medicine from ancient mummies,” said Dr. Frank Rühli, head of the Swiss Mummy Project at the University of Zurich in Switzerland, who is studying the internal organs of Iranian and Egyptian mummies.

“These historic patient records are like a box of candy for us.”

A crypt in the heart of a capital

In the heart of Vilnius, Lithuania’s Dominican Church of the Holy Spirit is a bright masterpiece of Late Baroque architecture. But it hides something darker.

Inside, an altar stands behind a large wooden platform where people kneel and pray. Beneath this is a stone staircase so narrow it can admit only one person at a time. Researchers liken it to an entrance to a secret lair: The steps descend to a dark and dusty underworld.

A black metal gate leads to the labyrinthine chambers that house the corpses. Once, there were body parts piled into a pyramid on the floor and stacked on shelves that reached to the ceiling.

Scientists have studied the mummies to gain insights into the lives of people in the 17th, 18th and 19th centuries and the diseases they suffered.CreditKiril Cachovski of the Lithuanian Mummy Project, 2015

For most of their history, the corpses were preserved intact: Cool temperatures and ventilation in the underground chamber had caused them to undergo spontaneous mummification. Though they faced disturbances over the centuries as the city and church were occupied by Napoleon, then the Nazis, it was the Soviet occupation of Lithuania that brought about a drastic change in the mummies’ fate.

In the 1960s, a forensic scientist named Juozas Albinas Markulis became one of the first to study the mummies. He wanted to know whether there were victims from World War II mixed in among the 17th-, 18th- and 19th-century corpses. (Oddly, Dr. Markulis is better known to Lithuanians not as a scientist but as a former spy who, while posing as a leader of the Lithuanian resistance, lured others into Soviet ambushes.)

Dr. Markulis and his students at Vilnius University identified 500 bodies in the crypt, of which about 200 had been mummified. In 1962, government officials inspected the crypt and ordered that the mummies be sealed behind glass, fearful that infected bodies might start an epidemic. They called it the Chamber of Death.

Soon a glass wall was erected, but it stopped the airflow and made the environment too humid and caused the mummies to decay. Dr. Markulis tried to save them, but his pleas were ignored by the Lithuanian government. The site was soon closed and remained unstudied until anthropologists returned to the chamber in 2004.

“Most people don’t realize you can learn about modern medicine from ancient mummies,” said Dr. Frank Rühli, head of the Swiss Mummy Project at the University of Zurich.CreditKiril Cachovski of the Lithuanian Mummy Project, 2015

From 2008 to 2011, researchers began inspecting and extracting the mummies from the crypt. Of the 200 studied by Dr. Markulis, who died in 1987, only 23 remained intact.

But while Dr. Markulis sought to uncover the identities of the mummies, Dr. Piombino-Mascali and his colleagues focused on how they lived.

Mummified medical mysteries

Looking at the remains, Dr. Piombino-Mascali identified several with dental decay and gum disease, as well as arthritis and bone deformities. To further investigate their health issues, he performed C.T. scans on the seven best-preserved mummies.

One obese man once had arthritis in his spine, pelvis and both knees, a fractured rib on his right side and an enlarged thyroid gland, which might have been caused by goiter. An obese woman had a benign tumor in her lower back. Both had suffered from clogged arteries, a health problem usually associated with modern diets.

Among the mummified bodies, the researchers found remnants of variola virus, which causes smallpox.CreditKiril Cachovski of the Lithuanian Mummy Project, 2015

“It was very strange,” Dr. Piombino-Mascali said of the examinations, “because we were not feeling as if they were just objects of cultural and archaeological interest. It was a feeling like they were with us willing to do a checkup for their medical conditions.”

The researchers sent samples from a 17th century mummified child to a colleague in Canada, who uncovered remnants of variola virus that causes smallpox, which once ravaged most of the world. By sequencing the virus, the team has gained insight into the origins of the deadly scourge.

“There was no evidence on any remains that would suggest a smallpox infection, so the presence of variola virus was very surprising,” said Ana Duggan, a biologist from McMaster University who worked with Dr. Piombino-Mascali. “It’s the oldest complete genome that we have of variola virus.”

She said the ancient DNA has helped them map out the timeline of smallpox. Historical accounts from Eygpt, China and India had suggested that smallpox had infected humans for thousands of years. But by comparing the 17th century strain with modern variola samples, they found the strains shared a common ancestor that emerged between 1530 and 1654. Their finding suggests that the deadliest kinds of smallpox may have evolved much more recently than previously thought.

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